The National Deuteration Facility offers the facilities, staff and expertise to produce molecules where all or part of the the molecular hydrogen is in the form of deuterium (2H or D).
The facility produces deuterated proteins, biopolymers, nucleic acids and synthesises small organic molecules such as lipids, phospholipids, sugars, surfactants, aliphatic hydrocarbons and aromatic, heterocyclic compounds. Double and triple labelling of proteins with both deuterium and the stable isotopes carbon-13 and/or nitrogen-15, are also available.
The facility offers molecular deuteration using either in vivo biodeuteration or chemical deuteration techniques.
Classes of deuterated molecules available
|Saturated fatty acids, alcohols, bromides, amines,
aldehydes, thiols, alkanes
|Partial and perdeuterated recombinant proteins|
|Saturated diacids and bifunctional surface active
|Double and triple labelled recombinant proteins|
|Deuterated silanes||Unsaturated fatty acids (e.g. oleic acid)|
|Membrane protein detergents (e.g. DDM and OG)||Glyme and glycol ethers|
|Deuterated surfactants including ionic and non-ionic||
Lipids including glycerides; phospholipids (e.g. DOPC and POPC);
|Aromatics and heterocyclics for MOFs||Compounds for organic light emitting diodes|
|Compounds for solar cells||Electrolytes for batteries|
|Selective deuteration of small molecules||Sugars|
|Biopolymers – cellulose, chitosan, chitin, PHAs||DNA|
Please consult our detailed catalogue for further information.
Proposals for user access are submitted through the Australian Centre for Neutron Scattering Customer Portal.
For all enquiries please contact: firstname.lastname@example.org
The National Deuteration Facility is partly supported by the National Collaborative Research Infrastructure Strategy – an initiative of the Australian Government.